Novel Pharmacological Strategies to Treat Cognitive Dysfunction in Copd

Grant number: 1139843 | Funding period: 2018 - 2022

Completed

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is a major incurable global health burden and is the 4th largest cause of death worldwide. Up to 60% of COPD patients suffer from cognitive dysfunction (i.e. a brain disorder which affects learning, memory, attention) which often leads to dementia. The reason for this is unknown so the aim of this study is to determine why people with COPD suffer from mental disorders then develop novel treatments to treat these disorders in COPD patients.

Related publications (3)

Ebselen prevents cigarette smoke-induced cognitive dysfunction in mice by preserving hippocampal synaptophysin expression

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Background: Cigarette smoking (CS) is the leading cause of chronic obstructive pulmonary disease (COPD). The “spill-over” of pulmo..

Cigarette Smoke Exposure Induces Neurocognitive Impairments and Neuropathological Changes in the Hippocampus

A Dobric, SN De Luca, HJ Seow, H Wang, K Brassington, SMH Chan, K Mou, J Erlich, S Liong, S Selemidis, SJ Spencer, S Bozinovski, R Vlahos

2022-05-17

Background and Objective: Neurocognitive dysfunction is present in up to ∼61% of people with chronic obstructive pulmonary disease..

Novel pharmacological strategies to treat cognitive dysfunction in chronic obstructive pulmonary disease

A Dobric, SN De Luca, SJ Spencer, S Bozinovski, MM Saling, CF McDonald, R Vlahos

2022-05-01

Chronic obstructive pulmonary disease (COPD) is a major incurable global health burden and currently the 3rd largest cause of deat..

University of Melbourne Researchers

Michael Saling